Selecting red blood cells for patients with hemoglobinopathies
Why did ICTMG develop a guideline for hemoglobinopathies?
Red blood cell transfusions are a life-sustaining therapy for patients with β-thalassemia or sickle cell disease, but having multiple transfusions puts them at high risk for alloimmunization. Alloimmunization is a well-documented complication of transfusion that increases the risk of delayed hemolytic transfusion reactions, complicates crossmatching and identifying compatible units, and delays provision of transfusions.
ICTMG's recommendations can help ensure these transfusion patients receive the red cell blood product that is optimal for them. The guideline is intended for transfusion medicine physicians as well as physicians intending to transfuse patients with hemoglobinopathies and apply to patients who require chronic or isolated red blood cell transfusion.
How to access the ICTMG publication
ICTMG's systematic review and guideline on transfusing red blood cells for patients with hemoglobinopathies was published in Transfusion in 2018:
Compernolle V, Chou ST, Tanael S, Savage W, Howard J, Josephson CD, Odame I, Hogan C, Denomme G, Shehata N; International Collaboration for Transfusion Medicine Guidelines. Red blood cell specifications for patients with hemoglobinopathies: a systematic review and guideline. Transfusion. 2018 Jun;58(6):1555-1566.
To download a pdf of the article click here:
Moderator: Dr. Shubha Allard
Speakers: Dr. Stella T. Chou and Dr. Gregory A. Denomme